Thats a far bigger concern than many people realise. Unlike licensed medicines, products sold through unregulated online suppliers may vary significantly in purity, concentration and quality
Its approval has already improved the lives of chronically overweight patients
Eating smaller meals, avoiding high-fat foods, and remaining upright after eating are recommended strategies
My general framework: Start with semaglutide if cost is a significant concern, or if there is no strong reason to expect poor tolerance Start with tirzepatide if the patient has tried semaglutide before and struggled with side effects, if faster initial response matters clinically, or if the patients goals require larger total weight loss Switch to tirzepatide if a patient on semaglutide is experiencing persistent nausea or has plateaued and escalation options are limited One pattern worth noting: men I see a consistent pattern with male patients who struggle to tolerate semaglutide nausea and GI disruption can be particularly disruptive for them, and theyre often less willing to push through it
Some patients may not want to use an injectable medication
Is Semaglutide GLP-1 better than liraglutide for individuals with a higher BMI
