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Of interest, treatment of aged rats with IGF-I was shown to upregulate eNOS and improve bioavailability of NO[295], and in vitro experiments in cultured endothelial cells demonstrated that IGF-I treatment reduce ROS production and upregulate eNOS[294]

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In studies reporting event counts, ALC arm events were mainly categorized as gastrointestinal (GI) and central nervous system (CNS), with other systems (skin/subcutaneous, urinary, cardiovascular, endocrine/metabolic, reproductive) reported infrequently

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