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Caffeine inhibits hepatitis C virus (HCV) replication in vitro and has been shown to dose-dependently inhibit HCV replication at non-cytotoxic concentrations, with an IC50 value of 0.7263 mM after 48 h of incubation

USA 120 , e2219086120 (2023)

It helps regulate various hormones and physiological processes in the body

Several mechanisms have been reported for the increased activity of NRF2 in cancers ( Figure 5 ): (1) somatic mutations in KEAP1 or NRF2 , (2) DNA hypermethylation at the promoter region of KEAP1 , (3) the aberrant accumulation of proteins that disrupt the KEAP1NRF2 interaction, (4) transcriptional up-regulation of NRF2 gene through oncogene-dependent signaling, and (5) the modification of KEAP1 protein through oncometabolites

(B) Compartmentation of glutathione in plant cells

Excess PUFA accumulation, depletion of GSH, and iron overload markedly heighten ferroptosis susceptibility