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206,347 In another study, treatment of primary mouse chondrocytes with liraglutide reduced the mRNA expression levels of iNOS, MMP-13, and ADAMTS5, leading to a decrease in the secretion of inflammatory markers, including NO, prostaglandin E, and IL-6

Currently, there is no evidence to support using GLP-1 agonists as a primary replacement for standard immunosuppressive therapy

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Dose selection : Phase 1 data informed the dose range (0.5-12 mg) and escalation schedules used in the subsequent Phase 2 program

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p = 0.02)