Chemotherapy is like trying to put out a fire in your kitchen by flooding the entire houseit causes massive collateral damage
Selected Data 1) The research team of Ma et al compared the therapeutic effects of peptides Liraglutide, Tirzepatide, and GLP-3R when administered to db/db mice experiencing diabetic kidney disease
These co-agonists have been shown to reduce glucose levels and body weight in people with overweight/obesity and type 2 diabetes, with nausea and vomiting the most frequently detected side effects (reviewed in [80, 81])
These numbers are unprecedented in the history of obesity pharmacotherapy
BM: Conceptualization, Data curation, Investigation, Methodology, Writing original draft, Writing review & editing
The GLP-1 and GIP arms meanwhile drive insulin secretion and gastric-emptying delay in different tissues and on different timescales (PMID 39515565, PMID 41785010)