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The drugs act in part as an appetite suppressant, which can dramatically reduce calorie intake to a concerning degree when not paired with nutritional guidance

Although not within the aim of this study, beta cell function may be indirectly determined by comparing the increase in AUC insulin after each of the glucose loads to AUC insulin after zero glucose

Although the rates of gallstone-related hospitalization were relatively low in both groups, at 1.5% per year in those on the very-low-calorie diet and 0.4% per year in those on the low-calorie diet, the results suggest that the health benefits of weight loss may be best achieved through modest calorie restriction (Johansson 2014)

trials in healthy adults are small and limited in scope

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