GLP-1 medications, like Semaglutide and Tirzepatide , are often prescribed to help manage symptoms of PCOS
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Additionally, incorporating strength training or muscle-building exercises, under medical guidance, can help you gain lean muscle mass and improve overall body composition
Combining with DPP-4 inhibitors is generally not recommended, as both drug classes work on the incretin system Adding basal insulin for those with more significant hyperglycaemia, which can be used alongside GLP-1 medications (with careful monitoring for hypoglycaemia) Switching to insulin therapy entirely may be necessary for those with advanced beta cell failure For weight management , when GLP-1 medications don't produce adequate weight loss, alternatives include: Orlistat , a lipase inhibitor that reduces fat absorption, though weight loss is typically modest (2-3 kg on average) Naltrexone-bupropion (Mysimba), which works on appetite centres through different pathways
Investigators have proposed this body-composition profile is consistent with the glucagon-receptor arm contributing energy-expenditure effects beyond simple appetite suppression
T1, T2, T3, and T4 for each hormone)
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