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In summary, tirzepatide achieved more pronounced HbA1c reductions with a lower incidence of hypoglycemia at week 52 compared to insulin glargine

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This is largely attributed to glucagon suppression and slow gastric emptying

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Elevated levels of TMAO-related metabolites have been associated with atherosclerosis, poor prognoses for atherosclerotic cardiovascular disease (ASCVD), and increased rates of major adverse cardiovascular events (MACE) 37,38,39,40

[DOI] [PMC free article] [PubMed] [Google Scholar] 39.Pelle M.C., Provenzano M., Zaffina I., Pujia R., Giofr F., Luc S., Andreucci M., Sciacqua A., Arturi F