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This cardiovascular outcomes trial of semaglutide versus placebo in patients with type 2 diabetes at high cardiovascular risk revealed an unexpected finding: patients receiving semaglutide experienced a statistically significant increase in diabetic retinopathy complications (hazard ratio 1.76, 95% CI 1.112.78, p=0.02)

McMorrow HE, Cohen AB, Lorch CM, Hayes NW, Fleps SW, Frydman JA, et al

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The maintenance of optimal reduced/oxidized ratios within cell compartments is crucial for healthy cellular redox 45 , and disruption caused by high concentrations of these substances could explain the observed adverse effects on cell viability

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