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A study found that metformin administration before and after MPTP injection (peri-treatment) was shown to protect TH + dopamine neurons from cell death through the upregulation of mitochondrial proteins, such as PGC-1a via activation of the ATF2-CREB pathway (Kang et al., 2017)

People experiencing fatigue: B12 plays a role in energy production, and supplementation may help alleviate fatigue

6.2 Need for IGF-1R targeting agents with higher specificity The drug candidates targeting IGF-1R signaling that are under clinical trial investigation include: IGF ligand inhibitors, which are monoclonal antibodies targeting IGF-1/2

You must use a sterile diluent like bacteriostatic water or sterile water for injection

Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society clinical practice guideline