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Why Doctors Often Miss Drug-Induced Depression: Clinicians are trained to consider disease before drug side effects

1 Introduction The global incidence of obesity and metabolic disorders is growing dramatically ( trans -unsaturated fatty acids, large portion sizes, and decreased physical activity ( Indeed, the roles of chemical and environmental factors are increasingly acknowledged ( The economic impact of chemically-induced metabolic disruption for the three groups of chemicals for which the weight of evidence of causing metabolic disruption in humans is strongest ( p,p -dichlorodiphenyldichloroethylene ( p,p -DDE), phthalates, bisphenol A (BPA)) is estimated to exceed 18 billion (with moderate probability) in Europe ( To address the need for elucidating and identifying metabolic disruption chemicals, the European Commission has dedicated funding to the development and (pre-)validation of test methods and Integrated Approaches to Testing and Assessment (IATA) under the Horizon 2020 Research and Innovation framework, to three projects of the EURION cluster: EDCMET ( aims to address the lack of methods for testing EDCs that disrupt metabolism and metabolic functions

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265 p38 MAPK and GSK3 have also been reported to phosphorylate SRC-3 on ser869 and ser505, which not only enhances its binding ability with AR but also determines the mode of action through ubiquitination

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