Williams struggle with weight loss post-retirement Williams has been open about struggling to lose weight post-retirement despite years of elite training
doi: 10.3389/fphar.2025.1591825 Received 11 March 2025 Accepted 28 August 2025 Published 08 October 2025 Volume 16 - 2025 Edited by Er Sheng Gong, Gannan Medical University, China Reviewed by Guillermo Federico Spitzmaul, National Scientific and Technical Research Council (CONICET), Argentina Leonardo Dionisio, National Scientific and Technical Research Council (CONICET), Argentina Updates Copyright 2025 Giannini, Soldi, Elli, Sagheddu, Castagnetti, Viciani, Salvini, Battistuzzi, Milazzo, Alibrandi and Sidoti
Their body is sending a "drink" signal because it does not have a separate signal for "you need salt." The body can only say "thirsty." It cannot say "your sodium is low, please eat something salty and then drink water." Sodium: the primary electrolyte concern Tirzepatide-induced natriuresis primarily affects sodium
These include: Dulaglutide (Trulicity) : Once-weekly injection with a single-dose pen featuring an automatic injection mechanism Semaglutide (Ozempic) : Once-weekly administration with dose escalation from 0.25 mg to maintenance doses of 0.5 mg, 1 mg, or 2 mg Exenatide extended-release (Bydureon BCise) : Once-weekly microsphere suspension requiring resuspension before injection Liraglutide (Victoza) : Once-daily injection available in a multi-dose pen For weight management, semaglutide 2.4 mg (Wegovy) and liraglutide 3.0 mg (Saxenda) are specifically FDA-approved
Mechanism: Supports mitochondrial ATP production to provide steady energy for cardiac muscle
Combined, the results are faster and more durable than either protocol alone