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While Janumet is generally considered safe, it can cause serious side effects in some cases

Leaving a reconstituted vial at room temperature for even a few hours can begin to significantly degrade its molecular structure, reducing its potency and effectiveness

Lingvay I, Manghi FP, Garca-Hernndez P et al (2016) Effect of insulin glargine up-titration vs insulin degludec/liraglutide on glycated hemoglobin levels in patients with uncontrolled type 2 diabetes: the DUAL V randomized clinical trial

Human clinical trials are scarce, and long-term safety, optimal dosing, and potential side effects remain unclear

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