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Frontiers in Molecular Biosciences

However, these positive findings were not replicated in a larger adult population by Guo et al., 2022) demonstrating that 3 months of supplementation with fish oil (providing 2.34 g/day EPA + DHA) plus 1680 IU VD 3 significantly reduced serum ALT, triglycerides, IR, and inflammatory markers including IL-1 and TNF- compared to placebo, with no reported side effects, while the combination therapy showed additional benefits over fish oil alone for insulin sensitivity and inflammation

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Furthermore, the sample size was relatively small

The most commonly reported adverse events are gastrointestinal (nausea, vomiting, diarrhea), typically mild to moderate and most frequent during dose escalation

Aoi, W., Ogaya, Y., Takami, M., Konishi, T., Sauchi, Y., Park, E