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One intriguing recent discovery is that gut microbes can produce small amounts of ammonia and other compounds that affect brain metabolism: a 2025 study showed that manipulating the gut microbiome altered brain amino acid levels and stress susceptibility in mice, partly via microbe-derived ammonia affecting neurotransmitter cycling [88]

GLP-1s also influence the part of the brain responsible for signaling hunger

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This is the first time that we have felt comfortable with the idea of making a compounded semaglutide offering available to patients and clinicians on Sesame, and so we're going to do it. How long will compounded semaglutides be available

Countless studies show oxidative stress in neurons is a marker of an unhealthy brain