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Second, establish baseline measurements for all relevant biomarkers before introducing either compound

If you are coming from tirzepatide, our guide on retatrutide dosing after tirzepatide addresses the specific considerations for that transition

These medicines work by mimicking the action of the naturally occurring hormone GLP-1, which stimulates insulin secretion, suppresses glucagon release, and slows gastric emptying

Liraglutide Treatment May Affect Renin and Aldosterone Release

The addition of glucagon receptor activation increases energy expenditure and fat oxidation

Store lyophilized retatrutide at -20C (long-term) or 2-8C (short-term)