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doi: 10.1016/j.lfs.2020.118731 166 AbdallaMADeshmukhHAtkinSSathyapalanT

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Excessively elevated IGF-1 suggests dosing higher than necessary

It also affects specific pathways known to be involved in energy balance and hunger or satiety signals in the central nervous system, such as the LCN2 pathway

The Clinical Data: Everything Published So Far Phase 1 First-in-Human (Oral Formulation) Published: The Lancet, June 2025 Participants: 144 adults with overweight or obesity (BMI 25.039.9), no diabetes Duration: Up to 12 weeks Dosing: Once-daily oral amycretin, up to 2 50 mg Results: - 50 mg dose: 10.4% mean body weight change - 2 50 mg dose: 13.1% mean body weight change - Placebo: 1.2% 13% weight loss in 12 weeks

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