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During the shortage, clinicians are also required to: Only prescribe GLP-1 RAs for their licensed indication Review the need for prescribing a GLP-1 RA agent and stop treatment if no longer required due to not achieving desired clinical effect as per NICE CG28 Avoid switching between brands of GLP-1 RAs, including between injectable and oral forms Where a higher dose preparation of GLP-1 RA is not available, do not substitute by doubling up a lower dose preparation Where GLP-1 RA therapy is not available, proactively identify patients established on the affected preparation and consider prioritising for review based on the criteria below

Feeling low energy on a caloric deficit is normal

This may partly explain why the old saying eat breakfast like a king, lunch like a prince and dinner like a pauper is backed by evidence that demonstrates greater weight loss when breakfast is the largest meal of the day and dinner is the smallest

The majority nearly 60% of people surveyed with annual incomes of more than $250,000 said the maximum price they are willing to pay out of pocket for a GLP-1 is more than $300 per month

Supplement-Based Approaches Selecting between berberine supplementation and GLP-1 therapy depends on your weight loss goals, timeline, and underlying metabolic profile

This gradual reduction may allow patients to adapt to increasing appetite and implement behavioral strategies progressively