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GLP-1R interactions with G s are conserved, however MD simulations reveal ligand-specific effects on interaction dynamics Overlay of the four consensus cryo-EM static structures revealed very similar backbone conformations of the intracellular face of receptor, with the greatest divergence for the ICLs (where modelled), and similar engagement with G s in all four peptide bound structures (Figure 8)

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Step 3: Choose the Right Formulation It is equally as important to choose the right formulation as it is to look for the best combination

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Before looking at how they work together, it is important to understand what these two powerhouse molecules do on their own