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Losing more lean tissue can lead to problems like frailty or even sarcopenia, a condition marked by extreme muscle wasting

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This is true for all weight loss methods, but particularly relevant with GLP-1 medications because the appetite suppression is so effective that severe caloric deficits can occur

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In addition, our results from annexin V/PI staining show that cell death follows a mainly apoptotic pattern, as evidenced by cells staining Annexin V + / PI (Table 1)