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Artificial enzyme catalyzed cascade reactions: Antitumor immunotherapy reinforced by NIR-II light

[27] [28] The result is a reduced lipoylation degree of important mitochondrial enzymes, such as pyruvate dehydrogenase complex (PDC) and -ketoglutarate dehydrogenase complex (-KGDHC)

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While the heme group is critical for its activity, past studies have also demonstrated the requirement of a tightly bound NADPH to the active conformation (39, 40)

62 SchnekenburgerM.MorceauF.DuvoixA.DelhalleS.TrentesauxC.DicatoM.et al (2004)