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Neuroprotection & cognitive function investigations

The Impact of High Uric Acid Levels High uric acid levels, known as hyperuricemia, can result in: Gout flares Kidney stones Potential kidney damage over time Understanding the factors that influence uric acid levels is vital for maintaining overall health

10.1016/j.phymed.2019.153090 46 DashS.PandaM

Potential explanations for these discrepancies are off-target effects of the compounds as well as the use physiological GSH concentrations (1 mM) but non-physiological CDNB concentrations (1 mM) in the corresponding enzyme assays

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(2013) Cell , 155(7): 16241638 Landmark study demonstrating that declining NAD+ with age disrupts nuclear-mitochondrial communication, creating a pseudohypoxic state in ageing muscle