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This degradation by DPP-4 is evaded because most GLP-1 analogues contain an amino acid substitution at the N-terminal end

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Moreover, in a xenograft mammary 4T1 tumor model, it has been demonstrated that the concurrent administration of BAPN and the enzyme-responsive drug (NQO1-SN38), designed to target breast tumors with the topoisomerase I inhibitor SN38, results in a cooperative reduction in tumor growth [100]

[2], and Chinevere et al