Collectively, these data suggest that choroid plexus epithelial cells are responsive to inducers of the Nrf2 pathway, and led us to hypothesize that their detoxifying capacity related to enzymatic conjugation to GSH can be enhanced by targeting this pathway
these are the same substances that make up the walls of human cells
McIntyre RS, Powell AM, Kaidanovich-Beilin O, Soczynska JK, Alsuwaidan M, Woldeyohannes HO, et al
Thyroid tumors: A special kind of thyroid tumors called Medullary thyroid cancer have been found in rodent studies, which is why the FDA puts a warning on liraglutide about the risk, but there havent been any studies on humans that show a connection
Lipidomic approach for stratification of acute myeloid leukemia patients
--- Here are some potential actions covered in the article for payers and employers to take as a result of this shift: Update formulary tiers and step therapy policies (consider the impact on comorbidities) Support members transitioning off GLP-1s after reaching their goals Create differentiated access pathways based on patient risk profiles Monitor realworld outcomes beyond A1C (cardiovascular, renal, adherence) Model the downstream impact on generics and legacy therapies --- Commercial plans are accelerating GLP-1 uptake and favoring the simplicity of a single therapy
