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The bioactivity results, however, showed that GLP-DARPin had a stronger blood glucose-lowering effect than GLP-2DARPin
Fig 2: Evolving Competitive Landscape in GLP-1 Based Obesity Medications Abbreviations: AHI: Apnea Hyperpnea Index, CKD: Chronic Kidney Disease, MONW: Metabolic Obesity Normal Weight, OOP: Out-of-pocket, OSA: Obstructive Sleep Apnea, WRC: Weight- related comorbidity
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Unlike traditional medications that primarily focus on insulin secretion or sensitivity, semaglutide mimics the incretin hormone GLP-1, enhancing glucose-dependent insulin release while reducing appetite