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2003;285:L313L321

For each eligible study, two authors (MM and AN) independently extracted data, which was then reviewed by a third author (JV) using a piloted spreadsheet, in accordance with Cochrane Collaboration guidelines ( Where relevant data were missing, attempts were made to contact corresponding authors

doi: 10.1016/j.marpolbul.2021.112059 3 BourboulouxA.ShahiP.ChakladarA.DelrotS.BachhawatA

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Must be diluted before administration - never inject undiluted Complete all dispensing within 4 hours of first vial puncture Contraindicated in patients with kidney stone history Use caution in patients with G6PD deficiency May interfere with glucose testing - inform laboratory staff Consult healthcare provider if pregnant or breastfeeding Clinical Applications Aesthetic Medicine High-dose vitamin C therapy for skin brightening, anti-aging, and overall complexion improvement