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Reported incidences in those receiving a 12mg/weekly dose of retatrutide were [21]: Nausea (45% of participants) Vomiting (19%) Constipation (16%) Diarrhea (15%) Cardiac arrhythmia (11%) Fatigue (10%) Increased pancreatic enzyme (lipase) levels (8%) Injection site reactions (8%) Liver issues in 2 participants (3%) Pancreatitis in 1 participant (2%) Both tirzepatide and retatrutide share similar contraindications, including advice against their use during pregnancy and breastfeeding

That is a much safer option

[DOI] [PMC free article] [PubMed] [Google Scholar] 130.Pangalangan J., Puma J., Tollefson M., Frates B

Kim HJ, Kang TU, Kim MJ, Swan H, Park SM

Neurochemical effects of the medication itself would gradually diminish after discontinuation

Some researchers argue that pulsatile peptide delivery, with peaks and troughs in plasma concentration, may produce different receptor signaling patterns than the sustained exposure from weekly injections