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The first tesamorelin human trials (Phase 1) began in the early 2000s, with Phase 3 trial dates spanning 2005-2008 (Study LIPO-010 Phase 3 completed 2008), leading to the November 2010 approval

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Dose-finding study of subcutaneously administered BI 456906 for 16 weeks, compared with placebo and open-label semaglutide in patients with type 2 diabetes mellitus

Each sample was then frozen and dried under vacuum

EClinicalMedicine 38 , 101019 (2021)

Tkalcevi VI, Cuzi S, Brajsa K, Mildner B, Bokuli A, Situm K, Perovi D, Glojnari I, Parnham MJ