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The synthesis in extrapineal sites presumably does not follow circadian rhythms, except for the retina, and mainly works as a local antioxidant 15,16

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Physical barriers include the dense extracellular matrix (ECM) and high interstitial fluid pressure

A., & Yanovski, S

SDHB, succinate dehydrogenase complex iron-sulfur subunit B

Last Updated: March 27, 2026 Sources of NADPH The reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) is critical to numerous reductive biosynthetic processes such as fatty acid synthesis, cholesterol synthesis, bile acid synthesis, steroid hormone synthesis, and deoxynucleotide synthesis