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doi: 10.1016/j.cub.2023.10.064 73 TilleyAEWaltersMSShaykhievRCrystalRG

Most protocols follow a gradual dose escalation schedule over 12 weeks before reaching maintenance doses

In this context, the data currently available on tirzepatide, showing its efficacy in glycemic control to the extent that a considerable percentage of patients achieve glucose levels indicative of diabetes remission [3, 59], as well as its high effectiveness in weight management, are promising regarding its future use in clinical practice

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36,37,38 Therefore, the weight loss results reported here are likely to underestimate the effect of the newer, more potent GLP-1 RAs semaglutide and tirzepatide