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This dual benefit likely stems from the fact that both overeating and nicotine dependence activate overlapping reward and addiction circuits in the brain

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12.2.2 Potential antagonistic effects Conversely, curcumin has been shown to interfere with the action of other chemotherapeutic drugs (e.g., cyclophosphamide, doxorubicin) by activating certain detoxification pathways (like ABC transporters) that pump the drugs out of cancer cells, thereby reducing their effectiveness (244)