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Adequate hydration and dietary fiber intake help manage this side effect

In large studies, prescription treatments like Wegovy have helped people lose around 15% of their body weight over time

Mounjaro/Zepbound (tirzepatide) is a GLP1/GIP dual agonist (~2022.5% loss)

TRIUMPH-1 confirmed 28.3% at 80 weeks in 2,339 patients (May 21, 2026) results consistent with bariatric surgery outcomes

But no published trial has shown retatrutide preserves lean mass better than GLP-1/GIP agents

Here are some examples of GLP-1 agonists: Dulaglutide (marketed as Trulicity) Exenatide (marketed as Byetta and Bydureon) Liraglutide (marketed as Victoza) Lixisenatide (marketed as Adlyxin) Semaglutide (marketed as Ozempic and Rybelsus) Glucagon-like Peptide-1 (GLP-1) Agonists Market Analysis: The Glucagon-like Peptide-1 (GLP-1) Agonists Market size is estimated at USD 11.87 billion in 2023, and is expected to reach USD 12.55 billion by 2028, growing at a CAGR of 1.12% during the forecast period (2023-2028)