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Moreover, it is worth mentioning that drug interaction and potent inhibitors of cytochrome P450 (CYP) 3A4 inhibitors (atorvastatin is metabolized by CYP3A4) can significantly increase statin concentrations (Hirota et al., 2020), and clinical research on atorvastatin tends to apply high dose (Pedersen et al., 2005) since high-dose atorvastatin is superior in preventing peripheral arterial disease (Stoekenbroek et al., 2015)

Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance

Neuropharmacology (2014) 76:5767

Interleukin-1 attenuates expression of augmenter of liver regeneration (ALR) by regulating HNF4 independent of c-Jun