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Nevertheless, This study provides the first evidence of a formulation-and dose-dependent ION risk, with the strongest association observed for Wegovy, write the researchers, concluding: These findings highlight a potential dose-dependent safety concern that warrants urgent prospective evaluation to guide prescribing and regulatory policy. The authors of a linked commentary agree

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Despite a number of mechanisms have been discussed in this review, most of the ROS-induced signaling targets are yet unknown

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