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This is a biphasic (hormetic) dose-response common with copper peptides and many other biological compounds

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Intraperitoneal, but not intracerebroventricular, administration of INSL-5 dose-dependently increases food intake in mice, indicating the peptide may exert its orexigenic effect by acting on peripheral targets, rather than via the CNS (164)

Valproic acid and chromatin remodeling in schizophrenia and bipolar disorder: Preliminary results from a clinical population

Monitoring disulfide bond formation in the eukaryotic cytosol