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This buildup causes HAGMA and is often underdiagnosed, particularly in patients with malnutrition, renal/liver impairment, sepsis, or interacting medications (e.g., flucloxacillin)

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A study on the intestinal microbiome of young and old mice has revealed that the gut microbial-derived metabolite 3-hydroxyphenylacetic acid upregulates GPX4 expression, inhibits ferroptosis, and alleviates spermatogenic dysfunction in aging mice [108]