Of the total cohort of participants, 47% of patients were women and the mean patient age was 66.2 years, the study results show
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Furthermore, when EX4 was co-expressed as a membrane-tethered protein, deletion of its first three residues had little effect on activation of the full-length GLP-1R, suggesting that the membrane-tethered expression could effectively increase the local concentrations of the fusion proteins (Figure 7c), which further supports that the N-terminal residues of EX4 are not required for activation of GLP-1R
