Schizophrenia is a debilitating and severe mental illness that affects approximately 1% of the general population worldwide.2 Schizophrenia is characterized by positive, negative, and cognitive symptoms with poor insight and impaired psychosocial function.3 Although acute psychosis is controlled with pharmacotherapy, negative and cognitive symptoms tend to be unresponsive to pharmacotherapy.456 In addition, most second-generation antipsychotics (SGA) except clozapine have been shown to have no significant advantages over first-generation antipsychotics (FGA) even in the domain of negative and cog-nitive symptoms.7 The chronicity and deterioration of the illness raise the possibility that schizophrenia may have neurodegenerative aspects
Clin Pharmacokinet 57:15291538
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