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Thus, we sought to identify a small-molecule GLP-1R agonist that is orally bioavailable using standard formulations, and has the potential to be combined with other oral small molecule therapeutics

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Nature (2020) 5797800:58691

Recent studies have suggested that I h currents can exert inhibitory effects by increasing the rheobase (minimum current required for firing), thereby reducing firing probability in small-diameter DRG neurons (Liu et al., 2022