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Despite the promising findings regarding the role of Clostridium and its metabolites in RA, several key issues remain to be addressed, including insufficient clinical evidence and unclear strain specificity

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In one single-center trial of 72 subjects using a controlled-adverse-environment model, the T4 eye drop did not meet its co-primary endpoints (ocular discomfort and inferior corneal staining) at the primary time point, but it did produce statistically significant improvements on several secondary endpoints, including central and superior corneal staining, with no adverse events reported