Body aches should be assessed if they are severe, persistent, associated with fever, muscle weakness, dark urine, chest pain or feeling very unwell
Managing Lower GI Issues: Constipation & Bloating The most common complaint on these medications is severe constipation
Dig Dis Sci 2023;68:1060-1070
Oral metabolic franchise, a broader portfolio of oral small molecule candidates targeting metabolic disease beyond the lead GLP-1 program Recent Highlights: In May 2026, Structure reported positive end-of-Phase 2 feedback from the FDA for aleniglipron, clearing the way to begin a Phase 3 registrational program for chronic weight management in Q3 2026
Once retatrutide is approved, you could switch
Weeks 13 onward: 12mg once weekly (target maintenance dose for maximum efficacy)