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Then, in 2015, Lee and colleagues identified a previously overlooked open reading frame within the 12S ribosomal RNA gene of mtDNA and found that it encodes a functional peptide, MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) [1]

Farhan Abdullah, the medical director at Magnolia Functional Wellness in suburban Dallas, said that over the past year, he's seen an uptick in moms, housewives, and "white collar people who are kind of approaching middle age" taking an interest in peptides

Additionally, LL-37 can undergo proteolytic processing to release smaller bioactive fragments with distinct functions (Bowdish et al., 2005)

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