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doi:10.1016/j.yexcr.2019.03.032

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Int J Mol Sci 23(7):4004 Koonrungsesomboon N, Sakuludomkan C, Na Takuathung M, Klinjan P, Sawong S, Perera PK (2024) Study design of herbal medicine clinical trials: a descriptive analysis of published studies investigating the effects of herbal medicinal products on human participants

The main practical disadvantages are: poor absorption in standard capsule form, the need for consistent daily use over 8-12+ weeks before visible results, relatively higher cost for well-absorbed formats, mild and uncommon side effects like digestive discomfort or headache in some users, and the risk of unrealistic expectations from aggressive marketing claims