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Nishiyama J, Matsuda K, Kakegawa W, Yamada N, Motohashi J, Mizushima N, et al

Possible Hormonal Shifts Although semaglutide mainly works by controlling appetite and blood sugar, it may also influence hormones in the body

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The researchers identified a phenomenon called GLP-1 resistance, in which the body produces higher levels of the hormone GLP-1 (glucagon-like peptide-1) but fails to respond to it properly