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The GTT indicated significantly lower blood glucose AUC in Donor+Cas9 treated mice compared to Saline and Donor groups at 8, 16, and 24 weeks post-injection, with levels comparable to non-treated mice fed with normal fat diet (Normal Diet) at matching time points

In addition, alternative pro-angiogenic signaling pathways including ANGPT-2, FGF-2, IL-8 can be induced by tumor cells in response to a pharmacological inhibition of the VEGF signaling pathway [297]

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A standard curve was plotted prior to each analytical run