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Specifically, phentermine triggers the release of norepinephrine from presynaptic vesicles in the lateral hypothalamus, the brain region that regulates hunger and satiety signals

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BMI 30.0 kg m 2 or 27.0 kg m 2 with the presence of at least one of the following weight-related comorbidities (treated or untreated): hypertension, dyslipidemia, obstructive sleep apnea or cardiovascular disease

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If dehydration is severe (little to no urination, extreme weakness, confusion), seek medical attention

For researchers transitioning from semaglutide or tirzepatide to retatrutide, the dose schedule requires a fresh start