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6 In the fifties, when chemotherapy wasnt available yet, children with neuroblastoma (a tumour of the autonomous nervous-system) received 1 mg B12 injections every other day during 2 to 3 years in a London childrens hospital

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It is not yet fully understood the mechanisms underlying BBB protection, but studies indicate it may be through a CD14-depenent mechanism, suppressing expression of LRP1, and protection from oxidative stress [146]