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This review stands out for its depth and scientific rigor, offering a solid foundation of knowledge that not only expands the understanding of reduced graphene oxide, but also sheds light on the effective use of natural reducing agents

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The typical protocol involves 1 to 3 mg per day for 10 to 20 consecutive days , followed by a break

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Under these conditions, NO triggers a programmed cell death with markers of both apoptosis and necrosis characterized by an early step of free radicals production followed by a late requirement for signaling on the sGC/cGMP/PKG pathway (Canals et al., 2001)

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