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This work calls into question our previous conclusion that TRFS-green is selective for TrxR and concludes based on the probe examined in their study that the apparent non-selective reactivity of 1,2-dithiolanebased molecules stems from the intrinsic chemistry of the ring rather than from variations in the conjugated cargo or linker

In: ENDO 201698th Annual Meeting of the Endocrine Society

In clinical trials, participants with obesity or who were overweight with weight-related health conditions lost an average of 15% to 22.5% of their body weight over 72 weeks, depending on the dosage