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Anti-diabetic agents and the risks of dementia in patients with type 2 diabetes: a systematic review and network meta-analysis of observational studies and randomized controlled trials

By inhibiting the NP (natriuretic peptide) system, sacubitril/valsartan increases natriuretic peptides (NPs) levels that, in turn, lead to vasodilation, natriuresis and RAAS inhibition through intracellular cyclic guanosine monophosphate (cGMP)-dependent pathways

Clinical trial protocols from the Phase 2 NEJM study used a gradual escalation approach, starting at low doses and increasing every four weeks

One study showed that GLP-1 levels were higher following the consumption of bread and olive oil compared to bread and butter

FLORA LICHTMAN: After the break, I want to dig into the mechanism or the possible mechanism of how these drugs might work for addiction and what these findings might tell us about the biology of addiction